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Roberto Frias, Porto, Portugal. Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone grafts. The association of biomaterials and cell-based therapies is a promising strategy for bone tissue engineering.

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Indeed, the microtomography roughness of the biomaterial has been demonstrated to be of the utmost importance to hDPSCs adhesion and osteopromotion [ 41 ], and that microconcave surfaces favour osteodifferentiation and formation of thick mineralized tissue by seeded cells, due to the resemblance to native bone trabecular Strufr [ 42 ]. J Mater Sci Mater Med ; 25 — Minimal criteria for defining multipotent mesenchymal stromal cells.

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